Drug-drug interaction (DDI) is a significant public health issue that accounts for 30% of unanticipated clinically hazardous medication events. The past decade has seen an evolution in informatics-based research for DDI signal identification. This paper aims to create an ensemble stacking machine learning (ML) approach capable of accurately predicting novel DDI hazard indicators. https://fitnessgravesyardes.shop/product-category/interface-board/