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Def6 is required for convergent extension movements during zebrafish gastrulation downstream of Wnt5b signaling.

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During gastrulation. convergent extension (CE) cell movements are regulated through the non-canonical Wnt signaling pathway. Wnt signaling results in downstream activation of Rho GTPases that in turn regulate actin cytoskeleton rearrangements essential for co-ordinated CE cell movement. Rho GTPases are bi-molecular switches that are inactive in their GDP-bound stage but can be activat... https://parisnaturalfoodes.shop/product-category/carnivor/
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